(Blood-ụbụrụ mgbochi, BBB)
Ihe mgbochi ụbụrụ ọbara bụ otu n'ime usoro nchebe onwe onye dị mkpa n'ime mmadụ.Ihe mejupụtara ya bụ mkpụrụ ndụ endothelial capillary ụbụrụ, sel glial, na choroid plexus, na-ekwe ka naanị ụdị mkpụrụ ndụ dị iche iche sitere na ọbara banye neuron ụbụrụ na sel ndị ọzọ gbara ya gburugburu, ma nwee ike igbochi ihe dị iche iche na-emerụ ahụ ịbanye n'anụ ahụ ụbụrụ.Ụbụrụ, dịka akụkụ nzuzo na akụkụ dị mkpa nke ahụ mmadụ, na-achịkwa ọtụtụ ọrụ dị mkpa.Ihe mgbochi ụbụrụ ọbara nwere ike igbochi ihe ndị na-emerụ ahụ dị n'ọbara ma chebe nchekwa nke anụ ahụ ụbụrụ.
Ọrịa Alzheimer, AD
Ọrịa Alzheimer (AD) bụ ọrịa neurodegenerative na-aga n'ihu na mmalite dị egwu.N'ihe omume ụlọ ọgwụ, a na-eji mgbaka zuru oke na-egosipụta site na nrụrụ ebe nchekwa, aphasia, aphasia, nkwụsị nke njirimara, adịghị ike nke anya na ohere ohere, nkwụsị ọrụ nchịkwa, na àgwà na mgbanwe omume.Etiology ka amabeghị.Nhụjuanya nke akaghi aka na-ezo aka na ndị mmadụ na-ebute mgbaàmà tupu ha eruo afọ 65;Ndị mmadụ n'otu n'otu na-etolite dementia mgbe afọ 65 gasịrị ka a na-ezo aka dị ka mgbaka agadi.A na-ejikọkarị ihe omume ọrịa Alzheimer (AD) na protein β-Amyloid (A β） Accumulation na Tau protein entanglement na-ejikọta ya, na ọtụtụ nyocha na-eji nwayọọ nwayọọ depụta neuroinflammation dị ka otu n'ime ihe ndị na-enye aka na omume AD.
Quote: Gịnị bụ ọrịa Alzheimer?Lelee ihe ọmụma a.Ndị mmadụ na ntanetị.2023-09-20
Rịba ama na e nwere ụdị nje bacteria nwere ike ịbanye n'ime mgbochi ụbụrụ ọbara
N'oge na-adịbeghị anya, ndị nchọpụta sitere na Baylor College of Medicine dị na United States bipụtara akwụkwọ nyocha nke akpọrọ: Ọnụ ego dị ka onye na-anabata 4 na CD11b gosipụtara na microglia coordinate erasure of Candida albicans cerebral mycosis in the Cell Reports sub journal.
Anyị achọpụtala ero a na-akpọ Candida albicans nke nwere ike ịbanye n'ụbụrụ site na ọbara.Dị ka okwu a ma ama na-ekwu, "Ịgba ụkwụ onye ngwọrọ nwere ike ịkpata ọrịa Alzheimer dị ka mgbanwe."N'ime ọmụmụ ihe a, anyị gara n'ihu kpughee usoro mkpụrụ ndụ nke Candida albicans na-agbaji site na mgbochi ụbụrụ ọbara ma banye n'ụbụrụ, na-eduga n'ọrịa Alzheimer dị ka mgbanwe.
Kedu ka Candida albicans si abanye n'ụbụrụ?"Anyị chọpụtara na Candida albicans na-emepụta enzyme a na-akpọ secreted aspartate protease (Saps), nke na-akpaghasị ihe mgbochi ụbụrụ ọbara, na-ekwe ka fungi banye n'ụbụrụ wee mebie," ka Dr. Yifan Wu, onye ọkà mmụta sayensị ụmụaka na-ahụ maka postdoctoral na-arụ ọrụ na Corry kwuru. Ụlọ nyocha.
Candida albicans
Candida albicans (aha sayensị: Candida albicans) bụ yist nke nwere ike ibute ọrịa ohere.A na-ahụkarị ya na mpaghara nje nke tract digestive na urogenital mmadụ.Ihe dị ka 40% ruo 60% nke ndị toro eto nwere ahụike Candida albicans na traktị ọnụ ha na nri nri.Candida albicans na-ebikọkarị n'ahụ mmadụ, mana ọ nwere ike itolite n'oge ụkọ mgbochi ọrịa ma bute candidiasis.Ọ bụ nje bacteria na-akpatakarị na Candida genus
Dị ka otu nnyocha e mere na Cell Reports si kwuo, fungi nke anyị na-adịghị elebara ya anya nke ukwuu pụkwara ịbụ otu n'ime ndị na-akpata ọrịa Alzheimer.Ndị na-eme nchọpụta sitere na Baylor School of Medicine na ụlọ ọrụ na-arụkọ ọrụ achọpụtala site na ụdị anụmanụ ka Candida albicans si abanye n'ụbụrụ na otú o si eme ka usoro abụọ nwere onwe ha na ụbụrụ ụbụrụ na-akwalite nkwụsị ya (nke dị oké mkpa maka ịghọta mmepe nke ọrịa Alzheimer), ma mepụtala. β Amyloid protein (A β) Peptides (iberibe protein na-egbu egbu nke protein amyloid) ka a na-ewere dị ka isi mmalite nke ọrịa Alzheimer.
Dr. David Corry kwuru.David Corry bụ onye isi oche nke Pathology na Fulbright Foundation na prọfesọ nke pathology, immunology, na ọgwụ na Mahadum Baylor.Ọ bụkwa onye otu Baylor L. Duncan Comprehensive Cancer Center.Na 2019, anyị chọpụtara na Candida albicans abanyela n'ụbụrụ n'ezie wee mepụta mgbanwe yiri nke ọrịa Alzheimer.Mbufụt nke Candida albicans na-esokarị
A β Ihe kpatara mmepụta nke amyloid dị ka peptides bụ na sap nwere ike hydrolyze amyloid precursor proteins (APPs).
Otú ọ dị, peptides ndị a na-adọtakwa uche nke ụbụrụ na-alụso ọrịa ọgụ - microglia, nke dị oké mkpa maka mwepu nke Candida albicans site na ụbụrụ n'onwe ya.Na mgbakwunye, Candidalysin toxin nke Candida albicans na-eme ka microglia rụọ ọrụ site n'ụzọ ọzọ.Ọ bụrụ na ụzọ a na-akpaghasị, fungi na ụbụrụ enweghị ike ikpochapụ.
Ndị nchọpụta na-arụtụ aka na ọrụ a nwere ike ịghọ ihe mgbagwoju anya dị mkpa maka ịghọta ihe na-eme ọrịa Alzheimer.Nnyocha ndị gara aga na-atụ aro na proteases na ụbụrụ na-etinye aka na nkwụsị nke ngwa ma na-enye aka na A β Nchịkọta nke tọrọ ntọala.Ma ugbu a enwere ike ikwenye na protease a na-apụ apụ sitere na fungi nwekwara ike ime ka A β Peptide dị ka mmepụta.
Ndị nchọpụta rụtụrụ aka na nyocha ọzọ nke ọrụ Candida albicans na mmepe nke ọrịa Alzheimer dị mkpa n'ọdịnihu, nke nwekwara ike iduga usoro ọgwụgwọ ọhụrụ maka AD.
Ihe nrụtụ aka:
[1] Yifan Wu et al, Toll dị ka onye nata 4 na CD11b gosipụtara na mkpochapụ microglia nke Candida albicans cerebral mycosis, Akụkọ Cell (2023) DOI: 10.1016/j.celrep.2023.113240
[2] Ọrịa na-arụ ọrụ ụbụrụ na-emepụta ọrịa Alzheimer dị ka mgbanwe, kwuru na eweghachiri ọmụmụ ọhụrụ October 17, 2023 site na https://medicalxpress.com/news/2023-10-brain-fungal-infection-alzheimer-disease-like.html
Oge nzipu: Dec-22-2023